Your 2025 Fall Vaccine Guide (Flu + COVID)
Last Update on September 04, 2025
Another respiratory season is here. If you're wondering what to do about flu and COVID shots this fall, you're not alone. At Ms.Medicine, we pride ourselves on our evidence-based focus. It's at the core of our mission, and our goal is to make medical decisions feel clear and manageable.
The short answer
Flu: Recommended for everyone 6 months and older. Aim for September or October so you're covered when cases rise. Adults 65+ should ask for a higher-dose or adjuvanted flu shot; if that's not available, any age-appropriate flu shot is fine.
COVID (2025–26 season): This year's updated shots were designed to better match currently circulating variants. As of late August, access is primarily focused on adults 65 and older and individuals at higher risk for severe illness (for example, those with certain chronic conditions). Your clinician or pharmacist can confirm if you qualify in your state.
Why these shots still matter
Flu and COVID vaccines are primarily aimed at keeping people out of the hospital and protecting those at the highest risk. Even when they don't prevent every infection, they help blunt severity and shorten recovery. That means more days feeling like yourself and fewer complications.
When to schedule
Flu: Book in September or October. If you miss that window, getting vaccinated later still helps.
COVID: If you're 65+ or high-risk, ask your clinician or pharmacist when updated doses are available near you and how they fit your situation. Policies can vary by state and pharmacy this year.
Recently had COVID? Many people choose to wait about 3 months after infection; the right timing depends on your risk and your provider's guidance.
Can I get both shots on the same day?
Some clinics and pharmacies offer a one-stop visit. It's also fine to space them out if that feels better to you. This topic is getting extra attention from regulators this fall, so the best approach is the one you and your clinician decide works for your body and schedule.
Special groups to keep top of mind
Adults 65+: You're a priority for both vaccines because age raises the risk of severe illness. For flu, ask about the higher-dose or adjuvanted options.
People with chronic conditions (heart or lung disease, diabetes, immune compromise, and others): You may be eligible for the updated COVID shot this year. Your primary care team can help you decide on timing and dosing.
Pregnancy: Flu vaccination is recommended during pregnancy; your OB can help you plan timing for flu and other vaccines.
Kids: Annual flu vaccination remains recommended for children 6 months and up. For COVID, ask your pediatrician about current eligibility and timing in your state.
What to expect after vaccination
Mild, short-lived side effects like a sore arm, fatigue, headache, or low-grade fever are common signs your immune system is doing its job. Most people feel better within 1–2 days. If you have a history of vaccine reactions or complex medical issues, check in with your clinician before you go.
How to make it easy this year
Book your flu shot now.
If you're 65+ or high-risk, call your pharmacy or clinician to ask when the updated COVID shot is available and whether you qualify.
Choose a plan you'll actually do: same-day visit or split appointments a couple of weeks apart. Either is okay.
Keep your receipts/cards so your medical team can see what you received and when.
A note about who we are
At Ms.Medicine, our mission is to close the gaps in women's healthcare. We bring evidence-based, sex-specific medicine to the forefront, translating complex science into clear guidance and advocating for care that sees the whole person. We champion prevention, including vaccines, because prevention saves lives. For personal recommendations, please contact your primary care provider.
